Research

This work examines genomic changes in primary melanomas and matched metastases from patients who later relapsed.

The preprint reports a six-gene copy-number signature associated with relapse and continued copy-number evolution in metastatic samples.

Clonal reconstruction and spatial measurements were used to examine seeding patterns and the organization of metastatic subclones.

Tumors contain malignant, immune, and stromal populations that can be studied together at single-cell and spatial resolution.

My first-author Clinical Cancer Research paper analyzes archival sarcomas and reports cellular programs associated with resistance to immune checkpoint blockade.

Collaborative work extends this interest to lung cancer brain metastases and single-cell measurements in a pancreatic cancer clinical study.

A Nature study on neuronal activity and small cell lung cancer provides another example of work examining interactions between tumors and their surrounding context.

This methods-development project asks how tissue mechanics relates to molecular and cellular organization in human tumors.

The planned approach combines atomic force microscopy with histology and spatial transcriptomics measured on adjacent sections.

Tissue registration is used to align physical measurements with spatial molecular information.

Related spatial publications are listed below; they are separate from this mechanics project.

This work addresses how health disparities can differ across communities often grouped under a single broad category.

The educational module focuses on disparities within Asian American, Native Hawaiian, and Pacific Islander populations.